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The Evolution of the Eukaryotic DNA Replication Machinery

October 28, 2025

The Evolution of the Eukaryotic DNA Replication Machinery

Image generated by Google Gemini

It is now well established that the remarkably complex eukaryotic DNA replication apparatus evolved from a related but simpler machinery found in present day archaea. However, the evolutionary events that underpin the duplication and diversification of replication factors have been enigmatic. A new study of the DNA replication machinery of Asgard archaea, just published in Nature Ecology and Evolution arising from a collaboration between Steve Bell’s lab and that of Professor Fabai Wu in the Eastern Institute of Technology, Ningbo, China has shed light on some of these key transitional events.