- Innate immunity: complement cascade, pathogen recognition, reactive oxygen and nitrogen, antimicrobial peptides, neutrophils, macrophage, and macrophage activation
- Adaptive immunity-humoral response: B lymphocytes, antibody production and antibody diversity, and memory immunity
- Adaptive immunity-cell mediated response: thymus, T lymphocytes, major histocompatibility complex (MHC), T cell receptors, antigen presenting cells, apoptosis, and superantigens
- Signaling: signal transduction cascades, interleukins and interleukin receptors, chemokines and chemokine receptors, interferons and antivirals
Successful students will be able to...
- Appreciate how several seminal immunological concepts were discovered.
- Describe the differences between innate and adaptive immune responses.
- Explain how innate immunity recognizes and eliminates microbial pathogens.
- Explain the multiple functions of the complement system.
- Understand how innate immune response initiates and enhances the adaptive immune response.
- Describe the cellular and humoral branches of adaptive immunity.
- Describe the origin, maturation, and function of T-cells.
- Understand antigen processing and presentation.
- Describe the origin, maturation, and function of B-cells.
- Understand antibody generation and the genetic basis for antibody diversity.
- Describe different types of antibodies and their functions.
- Explain multiple types of vaccines and how they work.
- Understand the basis of allergic reactions.
- Compare and contrast the different types of hypersensitivity reactions.
- Describe the immunological concepts relevant transplantation.
- Communicate how the innate and adaptive immune systems synergize to eliminate bacteria, viruses, or parasites.