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Igor Jouline

Igor Jouline

Igor Jouline

Rod Sharp Professor of Microbiology



Room 500, Aronoff Laboratory
318 W 12th Ave, Columbus, OH 43210

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Areas of Expertise

  • Signal transduction
  • Evolutionary genomics
  • Computational biology


  • B.S., Saratov State University, 1983
  • Ph.D., Saint Petersburg State University, 1988
  • Postdoc, University of Oxford, 1990-1991
  • Postdoc, Loma Linda University School of Medicine, 1992-1996




  • Distinguished Lecturer, American Society for Microbiology, 2022
  • Fellow, American Association for the Advancement of Science, 2019
  • Fellow, American Academy of Microbiology, 2017


Research Interests

We develop and apply computational genomics approaches to study molecular mechanisms and evolution of signal transduction. Our main focus is on prokaryotes, but we also study human genes that are implicated in diseases. Our credo is simple: Nature has already performed millions of genetic experiments; all we need to do is to carefully analyze the results. Most of our studies generate novel testable hypotheses that are often taken into experiment by our collaborators in "wet" laboratories.


Recent Publications

Gumerov VM*, Ulrich LE, Zhulin IB*. 2024. MiST 4.0: a new release of the microbial signal transduction database, now with a metagenome content. Nucleic Acids Res. 52: D647-D653.

Guo L, Wang YH, Cui R, Huang Z, Hong Y, Qian JW, Ni B, Xu AM, Jiang CY, Zhulin IB*, Liu SJ*, Li DF*. 2023. Attractant and repellent induce opposing changes in the four-helix bundle ligand-binding domain of a chemoreceptor. PLoS Biology 21: e3002429.

Cerna-Vargas JP, Gumerov VM, Krell T*, Zhulin IB*. 2023. Amine-recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor. Proc. Natl. Acad. Sci. USA 120: e2305837120.

Xing J, Gumerov VM, Zhulin IB*. 2023. Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor. Sci. Adv. 9: eadi4517.

Andrianova EP, Marmion RA, Shvartsman SY*, Zhulin IB*. 2023. Evolutionary history of MEK1 illuminates the nature of deleterious mutations. Proc. Natl. Acad. Sci. USA 120: e2304184120.

Gumerov VM, Andrianova EP, Matilla MA, Page KM, Monteagudo-Cascales E, Dolphin AC, Krell T*, Zhulin IB*. 2022. Amino acid sensor conserved from bacteria to humans. Proc. Natl. Acad. Sci. USA 119: e2110415119.

Gumerov VM, Andrianova EP, Zhulin IB*. 2021. Diversity of bacterial chemosensory systems. Curr. Opin. Microbiol. 61: 42-50.



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