Igor Jouline
Rod Sharp Professor of Microbiology
Room 500, Aronoff Laboratory
318 W 12th Ave, Columbus, OH 43210
Areas of Expertise
- Signal transduction
- Evolutionary genomics
- Computational biology
Education
- B.S., Saratov State University, 1983
- Ph.D., Saint Petersburg State University, 1988
- Postdoc, University of Oxford, 1990-1991
- Postdoc, Loma Linda University School of Medicine, 1992-1996
Affiliations
Awards
- Distinguished Lecturer, American Society for Microbiology, 2022
- Fellow, American Association for the Advancement of Science, 2019
- Fellow, American Academy of Microbiology, 2017
Research Interests
We develop and apply computational genomics approaches to study molecular mechanisms and evolution of signal transduction. Our main focus is on prokaryotes, but we also study human genes that are implicated in diseases. Our credo is simple: Nature has already performed millions of genetic experiments; all we need to do is to carefully analyze the results. Most of our studies generate novel testable hypotheses that are often taken into experiment by our collaborators in "wet" laboratories.
Recent Publications
Monteagudo-Cascales E, Gavira JA, Xing J, Velando F, Matilla MA, Zhulin IB*, Krell T*. 2025. Bacterial sensor evolved by decreasing complexity. Proc. Natl. Acad. Sci. USA 122: e2409881122.
Halte M*, Andrianova EP, Goosmann C, Chevance FFV, Hughes KT, Zhulin IB, Erhardt M*. 2024. FlhE functions as a chaperone to prevent formation of periplasmic flagella in Gram-negative bacteria. Nat. Commun. 15: 5921.
Monteagudo-Cascales E, Gumerov VM, Fernandez M, Matilla MA, Gavira JA, Zhulin IB*, Krell T*. 2024.Ubiquitous purine sensor modulates diverse signal transduction pathways in bacteria. Nat. Commun. 15: 5867.
Ross PA, Xu W, Jalomo-Khayrova E, Bange G, Gumerov VM, Bradley PH, Sourjik V*, Zhulin IB*. 2024. Framework for exploring the sensory repertoire of the human gut microbiota. mBio 15: e0103924.
Gumerov VM*, Ulrich LE, Zhulin IB*. 2024. MiST 4.0: a new release of the microbial signal transduction database, now with a metagenome content. Nucleic Acids Res. 52: D647-D653.
Guo L, Wang YH, Cui R, Huang Z, Hong Y, Qian JW, Ni B, Xu AM, Jiang CY, Zhulin IB*, Liu SJ*, Li DF*. 2023. Attractant and repellent induce opposing changes in the four-helix bundle ligand-binding domain of a chemoreceptor. PLoS Biol. 21: e3002429.
Cerna-Vargas JP, Gumerov VM, Krell T*, Zhulin IB*. 2023. Amine-recognizing domain in diverse receptors from bacteria and archaea evolved from the universal amino acid sensor. Proc. Natl. Acad. Sci. USA 120: e2305837120.
Xing J, Gumerov VM, Zhulin IB*. 2023. Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor. Sci. Adv. 9: eadi4517.
Andrianova EP, Marmion RA, Shvartsman SY*, Zhulin IB*. 2023. Evolutionary history of MEK1 illuminates the nature of deleterious mutations. Proc. Natl. Acad. Sci. USA 120: e2304184120.
Gumerov VM, Andrianova EP, Matilla MA, Page KM, Monteagudo-Cascales E, Dolphin AC, Krell T*, Zhulin IB*. 2022. Amino acid sensor conserved from bacteria to humans. Proc. Natl. Acad. Sci. USA 119: e2110415119.