Rod Sharp Professor in Microbiology
500 Aronoff Laboratory
Areas of Expertise
- Signal transduction
- Evolutionary genomics
- Computational biology
- B.S., Saratov State University, 1983
- Ph.D., Saint Petersburg State University, 1988
- American Association for the Advancement of Science, Fellow, 2019
- American Academy of Microbiology, Fellow, 2017
We develop and apply computational genomics approaches to study molecular mechanisms and evolution of signal transduction. Our main focus is on prokaryotes, but we also study human genes that are implicated in diseases ranging from Mendelian disorders to cancer. Our credo is simple: Nature has already performed millions of genetic experiments; all we need to do is to carefully analyze the results. Most of our studies generate novel testable hypotheses that are often taken into experiment by our collaborators in "wet" laboratories.
Gumerov VM, Zhulin IB. 2020. TREND: a platform for exploring protein function in prokaryotes based on phylogenetic, domain architecture and gene neighborhood analyses. Nucleic Acids Res. doi: 10.1093/nar/gkaa243. Online ahead of print.
Gumerov VM, Ortega DR, Adebali O, Ulrich LE, Zhulin IB. 2020. MiST 3.0: an updated microbial signal transduction database with an emphasis on chemosensory systems. Nucleic Acids Res. 48: D459-D464.
Muok AR, Deng Y, Gumerov VM, Chong JE, DeRosa JR, Kurniyati K, Coleman RE, Lancaster KM, Li C, Zhulin IB, Crane BR. 2019. A di-iron protein recruited as an Fe[II] and oxygen sensor for bacterial chemotaxis functions by stabilizing an iron-peroxy species. Proc. Natl. Acad. Sci. USA 116: 14955-14960.
Ortega DR, Fleetwood AD, Krell T, Harwood CS, Jensen GJ, Zhulin IB. 2017. Assigning chemoreceptors to chemosensory pathways in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. USA 114: 12809-12814.
Ortega Á, Zhulin IB, Krell T. 2017. Sensory repertoire of bacterial chemoreceptors. Microbiol. Mol. Biol. Rev. 81: e00033-17.
Upadhyay AA, Fleetwood AD, Adebali O, Finn RD, Zhulin IB. 2016. Cache domains that are homologous to, but different from PAS domains comprise the largest superfamily of extracellular sensors in prokaryotes. PLoS Comput. Biol. 12: e1004862.
Adebali O, Reznik AO, Ory DS, Zhulin IB. 2016. Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations. Genet. Med. 18: 1029-1036.
Ortega DR, Yang C, Ames P, Baudry J, Parkinson JS, Zhulin IB. 2013. A phenylalanine rotameric switch for signal-state control in bacterial chemoreceptors. Nat. Commun. 4: 2881.
Wuichet K, Zhulin IB. 2010. Origins and diversification of a complex signal transduction system in prokaryotes. Sci. Signal. 3: ra50.
Ulrich LE, Koonin EV, Zhulin IB. 2005. One-component systems dominate signal transduction in prokaryotes. Trends Microbiol. 13: 52-56.