M7070 Antibiotics

 

Credit: 3 Units

Instructor: Fredrick

Offered: Spring

                  

Lecture topics:

  • Major classes of medically important antibiotics and their modes of action
  • Mechanisms of resistance
  • Inhibitors of peptidoglycan synthesis
  • Inhibitors of translation
  • Inhibitors of transcription
  • Inhibitors of DNA topoisomerases
  • Antibiotics as effectors of gene expression
  • Mechanisms of horizontal gene transfer
  • Polyketide antibiotic biosynthesis
  • Bacterial persisters
  • Human microbiome and impacts of antibiotics

Learning Outcomes:

Successful students will be able to…

  • Knowledgably describe the major types of antibiotics and their modes of action
  • Knowledgably describe the common mechanisms of antibiotic resistance
  • Discuss the biosynthesis of the polyketide antibiotics
  • Understand current views on the roles of antibiotics in nature and the origin of resistance genes
  • Read and critically evaluate research papers in microbiology
  • Understand commonly employed methods in microbiology research
  • Accurately interpret raw and processed data sets in research papers
  • Identify key findings of research papers
  • Present key findings of research papers clearly to an audience of peers
  • Identify strong arguments supported by conclusive data; identify weak arguments supported by inconclusive data
  • Argue the merits and/or weaknesses of published work from a knowledgeable perspective
  • Read research papers with high efficiency

 

 

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